Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
JY Park, MH Pillinger, SB Abramson - Clinical immunology, 2006 - Elsevier
Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as
rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs)
and selective cyclooxygenase-2 (COX-2) inhibitors reduce PGE2 production to diminish the
inflammation seen in these diseases, but have toxicities that may include both
gastrointestinal bleeding and prothrombotic tendencies. In cells, arachidonic acid is
transformed into PGE2 via cyclooxygenase (COX) enzymes and terminal prostaglandin E …
rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs)
and selective cyclooxygenase-2 (COX-2) inhibitors reduce PGE2 production to diminish the
inflammation seen in these diseases, but have toxicities that may include both
gastrointestinal bleeding and prothrombotic tendencies. In cells, arachidonic acid is
transformed into PGE2 via cyclooxygenase (COX) enzymes and terminal prostaglandin E …