A consensus epitope prediction approach identifies the breadth of murine TCD8+-cell responses to vaccinia virus
M Moutaftsi, B Peters, V Pasquetto, DC Tscharke… - Nature …, 2006 - nature.com
Nature biotechnology, 2006•nature.com
The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not
been adequately tested experimentally. Here we demonstrate that conventional
bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia
virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of
T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide
a tool for developing comprehensive antigenic maps of any complex pathogen.
been adequately tested experimentally. Here we demonstrate that conventional
bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia
virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of
T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide
a tool for developing comprehensive antigenic maps of any complex pathogen.
Abstract
The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
nature.com