[HTML][HTML] TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
B Ey, A Eyking, G Gerken, DK Podolsky… - Journal of biological …, 2009 - ASBMB
Gap junctional intercellular communication (GJIC) coordinates cellular functions essential
for sustaining tissue homeostasis; yet its regulation in the intestine is not well understood.
Here, we identify a novel physiological link between Toll-like receptor (TLR) 2 and GJIC
through modulation of Connexin-43 (Cx43) during acute and chronic inflammatory injury of
the intestinal epithelial cell (IEC) barrier. Data from in vitro studies reveal that TLR2
activation modulates Cx43 synthesis and increases GJIC via Cx43 during IEC injury. The …
for sustaining tissue homeostasis; yet its regulation in the intestine is not well understood.
Here, we identify a novel physiological link between Toll-like receptor (TLR) 2 and GJIC
through modulation of Connexin-43 (Cx43) during acute and chronic inflammatory injury of
the intestinal epithelial cell (IEC) barrier. Data from in vitro studies reveal that TLR2
activation modulates Cx43 synthesis and increases GJIC via Cx43 during IEC injury. The …