[HTML][HTML] Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase: implications for early atherogenesis and ceramide …
S Marathe, SL Schissel, MJ Yellin, N Beatini… - Journal of Biological …, 1998 - ASBMB
We recently reported that macrophages and fibroblasts secrete a Zn 2+-dependent
sphingomyelinase (S-SMase), which, like lysosomal SMase, is a product of the acid SMase
gene. S-SMase may cause subendothelial retention and aggregation of lipoproteins during
atherogenesis, and the acid SMase gene has been implicated in ceramide-mediated cell
signaling, especially involving apoptosis of endothelial cells. Because of the central
importance of the endothelium in each of these processes, we now sought to examine the …
sphingomyelinase (S-SMase), which, like lysosomal SMase, is a product of the acid SMase
gene. S-SMase may cause subendothelial retention and aggregation of lipoproteins during
atherogenesis, and the acid SMase gene has been implicated in ceramide-mediated cell
signaling, especially involving apoptosis of endothelial cells. Because of the central
importance of the endothelium in each of these processes, we now sought to examine the …