PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
R Göggel, S Winoto-Morbach, G Vielhaber, Y Imai… - Nature medicine, 2004 - nature.com
R Göggel, S Winoto-Morbach, G Vielhaber, Y Imai, K Lindner, L Brade, H Brade, S Ehlers…
Nature medicine, 2004•nature.comPlatelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung
injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms:
acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the
cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such
as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by
PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide …
injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms:
acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the
cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such
as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by
PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide …
Abstract
Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.
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