[HTML][HTML] Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice1
DQH Wang, S Tazuma - Journal of lipid research, 2002 - ASBMB
This study investigated whether β-muricholic acid, a natural trihydroxy hydrophilic bile acid
of rodents, acts as a biliary cholesterol-desaturating agent to prevent cholesterol gallstones
and if it facilitates the dissolution of gallstones compared with ursodeoxycholic acid (UDCA).
For gallstone prevention study, gallstone-susceptible male C57L mice were fed 8 weeks
with a lithogenic diet (2% cholesterol and 0.5% cholic acid) with or without 0.5% UDCA or β-
muricholic acid. For gallstone dissolution study, additional groups of mice that have formed …
of rodents, acts as a biliary cholesterol-desaturating agent to prevent cholesterol gallstones
and if it facilitates the dissolution of gallstones compared with ursodeoxycholic acid (UDCA).
For gallstone prevention study, gallstone-susceptible male C57L mice were fed 8 weeks
with a lithogenic diet (2% cholesterol and 0.5% cholic acid) with or without 0.5% UDCA or β-
muricholic acid. For gallstone dissolution study, additional groups of mice that have formed …