[HTML][HTML] Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice [S]
ED Bischoff, CL Daige, M Petrowski, H Dedman… - Journal of lipid …, 2010 - ASBMB
The liver X receptors LXRα and LXRβ play critical roles in maintaining lipid homeostasis by
functioning as transcription factors that regulate genetic networks controlling the transport,
catabolism, and excretion of cholesterol. The studies described in this report examine the
individual anti-atherogenic activity of LXRα and LXRβ and determine the ability of each
subtype to mediate the biological response to LXR agonists. Utilizing individual knockouts of
LXRα and LXRβ in the Ldlr−/− background, we demonstrate that LXRα has a dominant role …
functioning as transcription factors that regulate genetic networks controlling the transport,
catabolism, and excretion of cholesterol. The studies described in this report examine the
individual anti-atherogenic activity of LXRα and LXRβ and determine the ability of each
subtype to mediate the biological response to LXR agonists. Utilizing individual knockouts of
LXRα and LXRβ in the Ldlr−/− background, we demonstrate that LXRα has a dominant role …