One of the most common forms of functional interaction among transcription factors is the
more than additive effect at promoters harboring multiple copies of a response element. The
mechanisms that enable or control synergy at such compound response elements are
poorly understood. We recently defined a common motif within the negative regulatory
regions of multiple factors that operates by regulating their transcriptional synergy. We have
identified such a synergy control (SC) motif embedded within the" attenuator domain" of …