Post-translational modification by SUMO

Z Hannoun, S Greenhough, E Jaffray, RT Hay, DC Hay - Toxicology, 2010 - Elsevier
Post-translational modifications (PTMs) are chemical alterations to a protein following
translation, regulating stability and function. Reversible phosphorylation is an example of an
important and well studied PTM involved in a number of cellular processes. SUMOylation is
another PTM known to modify a large number of proteins and plays a role in various cellular
processes including: cell cycle regulation, gene transcription, differentiation and cellular
localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the …