[HTML][HTML] Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma

K Ishii, SB Shappell, RJ Matusik, SW Hayward - Laboratory investigation, 2005 - Elsevier
Transgenic mouse models of cancer represent a powerful approach for exploring disease
processes and testing potential therapeutic interventions. Currently, it is difficult to predict if a
specific genetic manipulation will result in a desirable phenotype. The present study tests
the idea that tissue recombinants recapitulate the pathologic features of the neoplastic
prostate seen in transgenic mice, and would thus be suitable predictive models for new
mouse design. The large probasin-large T-antigen (LPB-Tag) transgenic lines 12T-7f and …