Insulin in the brain

DG Baskin, DP Figlewicz, SC Woods… - Annual review of …, 1987 - annualreviews.org
DG Baskin, DP Figlewicz, SC Woods, D Porte Jr, DM Dorsa
Annual review of physiology, 1987annualreviews.org
The central nervous system (eNS) has traditionally been considered to be independent of
the influence of insulin. However, in the last few years new evidence has indicated that
insulin and its receptors are present in the eNS, and physiological, behavioral, and
developmental influences of central inн sulin on the eNS have been documented. There is
evidence that plasma insulin has relatively rapid access to cerebrospinal fluid (eSF), that
CSF insulin concentrations affect feeding behavior and body weight, and that insulin may act …
The central nervous system (eNS) has traditionally been considered to be independent of the influence of insulin. However, in the last few years new evidence has indicated that insulin and its receptors are present in the eNS, and physiological, behavioral, and developmental influences of central inн sulin on the eNS have been documented. There is evidence that plasma insulin has relatively rapid access to cerebrospinal fluid (eSF), that CSF insulin concentrations affect feeding behavior and body weight, and that insulin may act as a eNS neuromodulator. The present review focuses on important unanswered questions and problems regarding insulin in the CNS
Annual Reviews