Akt activity in Alzheimer's disease and other neurodegenerative disorders
A Rickle, N Bogdanovic, I Volkman, B Winblad… - …, 2004 - journals.lww.com
Enzyme activities of the serine/threonine kinase Akt were compared in mid-temporal and
mid-frontal cortices from Alzheimer's disease cases and matched controls. Activities (GSK-
3α/β fusion protein phosphorylation by immunoprecipitated Akt) were significantly increased
in temporal cortex soluble fractions from Alzheimer's disease compared with non-disease
controls and positive disease controls with another neurodegenerative disease. Temporal
cortex soluble fraction Akt activities positively correlated with Braak staging for neurofibrillary …
mid-frontal cortices from Alzheimer's disease cases and matched controls. Activities (GSK-
3α/β fusion protein phosphorylation by immunoprecipitated Akt) were significantly increased
in temporal cortex soluble fractions from Alzheimer's disease compared with non-disease
controls and positive disease controls with another neurodegenerative disease. Temporal
cortex soluble fraction Akt activities positively correlated with Braak staging for neurofibrillary …