The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals
G Reaven - Endocrinology and Metabolism Clinics, 2004 - endo.theclinics.com
Sensitivity to insulin-mediated glucose disposal varies widely in the population at large [1].
When insulin-resistant individuals cannot maintain the degree of hyperinsulinemia needed
to overcome the insulin resistance, type 2 diabetes develops [2, 3]. Most individuals are able
to sustain the level of compensatory hyperinsulinemia needed to maintain normal or
nearnormal glucose tolerance, however. Unfortunately, this philanthropic effort on the part of
the pancreatic beta cell is a mixed blessing. Although the compensatory hyperinsulinemia …
When insulin-resistant individuals cannot maintain the degree of hyperinsulinemia needed
to overcome the insulin resistance, type 2 diabetes develops [2, 3]. Most individuals are able
to sustain the level of compensatory hyperinsulinemia needed to maintain normal or
nearnormal glucose tolerance, however. Unfortunately, this philanthropic effort on the part of
the pancreatic beta cell is a mixed blessing. Although the compensatory hyperinsulinemia …