[HTML][HTML] Brain insulin receptors and spatial memory: correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of …
W Zhao, H Chen, H Xu, E Moore, N Meiri… - Journal of Biological …, 1999 - ASBMB
Evidence accumulated from clinical and basic research has indirectly implicated the insulin
receptor (IR) in brain cognitive functions, including learning and memory (Wickelgren,
I.(1998) Science 280, 517–519). The present study investigates correlative changes in IR
expression, phosphorylation, and associated signaling molecules in the rat hippocampus
following water maze training. Although the distribution of IR protein matched that of IR
mRNA in most forebrain regions, a dissociation of the IR mRNA and protein expression …
receptor (IR) in brain cognitive functions, including learning and memory (Wickelgren,
I.(1998) Science 280, 517–519). The present study investigates correlative changes in IR
expression, phosphorylation, and associated signaling molecules in the rat hippocampus
following water maze training. Although the distribution of IR protein matched that of IR
mRNA in most forebrain regions, a dissociation of the IR mRNA and protein expression …