[HTML][HTML] Water-soluble Aβ (N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains (∗)
YM Kuo, MR Emmerling, C Vigo-Pelfrey… - Journal of Biological …, 1996 - ASBMB
Ultracentrifugation and graded molecular sieving, as well as a sensitive sandwich enzyme-
linked immunosorbent assay were used to isolate and quantitate the amounts of water-
soluble oligomers of β amyloid (Aβ) peptides N-40 and N-42 in cerebral cortex of normal
and Alzheimer disease (AD) brains. AD brains contained 6-fold more water-soluble Aβ
(wsAβ) than control brains. The majority of water-soluble peptides in most AD cases was Aβ
N-42, representing 12 times the amount found in control brains. The wsAβ was present in …
linked immunosorbent assay were used to isolate and quantitate the amounts of water-
soluble oligomers of β amyloid (Aβ) peptides N-40 and N-42 in cerebral cortex of normal
and Alzheimer disease (AD) brains. AD brains contained 6-fold more water-soluble Aβ
(wsAβ) than control brains. The majority of water-soluble peptides in most AD cases was Aβ
N-42, representing 12 times the amount found in control brains. The wsAβ was present in …