Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis

C Natanson, SJ Kern, P Lurie, SM Banks, SM Wolfe - Jama, 2008 - jamanetwork.com
Context Hemoglobin-based blood substitutes (HBBSs) are infusible oxygen-carrying liquids
that have long shelf lives, have no need for refrigeration or cross-matching, and are ideal for
treating hemorrhagic shock in remote settings. Some trials of HBBSs during the last decade
have reported increased risks without clinical benefit. Objective To assess the safety of
HBBSs in surgical, stroke, and trauma patients. Data Sources PubMed, EMBASE, and
Cochrane Library searches for articles using hemoglobin and blood substitutes from 1980 …