[HTML][HTML] Differential protein expression profiling by iTRAQ-two-dimensional LC-MS/MS of human bladder cancer EJ138 cells transfected with the metastasis …

I Ruppen, L Grau, E Orenes-Pinero, K Ashman… - Molecular & Cellular …, 2010 - ASBMB
KiSS-1 is a metastasis suppressor gene reported to be involved in the progression of
several solid neoplasias. The loss of KiSS-1 gene expression has been shown to be
inversely correlated with increasing tumor stage, distant metastases, and poor overall
survival in bladder tumors. To identify the molecular pathways associated with the
metastasis suppressor role of KiSS-1 in bladder cancer, we carried out a proteomics
analysis of bladder cancer cells (EJ138) transiently transfected with a vector encompassing …