Sirolimus blocks the accumulation of hyaluronan (HA) by arterial smooth muscle cells and reduces monocyte adhesion to the ECM
Y Gouëffic, S Potter-Perigo, CK Chan, PY Johnson… - Atherosclerosis, 2007 - Elsevier
Sirolimus (SRL), an inhibitor of human arterial smooth muscle cell (ASMC) proliferation and
migration, prevents in-stent restenosis (ISR). Little is known about the effect of SRL on the
extracellular matrix (ECM) component, hyaluronan, a key macromolecule in neointimal
hyperplasia and inflammation. In this study, we investigated SRL regulation of the synthesis
of hyaluronan by cultured human ASMC and the effect of SRL on hyaluronan mediated
monocyte adhesion to the ECM. Hyaluronan production on a per cell basis was significantly …
migration, prevents in-stent restenosis (ISR). Little is known about the effect of SRL on the
extracellular matrix (ECM) component, hyaluronan, a key macromolecule in neointimal
hyperplasia and inflammation. In this study, we investigated SRL regulation of the synthesis
of hyaluronan by cultured human ASMC and the effect of SRL on hyaluronan mediated
monocyte adhesion to the ECM. Hyaluronan production on a per cell basis was significantly …