ADAMTS-4 and-8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques
D Wågsäter, H Björk, C Zhu, J Björkegren, G Valen… - Atherosclerosis, 2008 - Elsevier
OBJECTIVES: Remodeling of extracellular matrix (ECM) plays an important role in
inflammatory disorders such as atherosclerosis. ADAMTS (a disintegrin and
metalloproteinase with thrombospondin motifs) is a recently described family of proteinases
that is able to degrade the ECM proteins aggrecan and versican expressed in blood vessels.
The purpose of the present study was to analyze the expression and regulation of several
ADAMTSs before and after macrophage differentiation and after stimulation with IFN-γ, IL-1β …
inflammatory disorders such as atherosclerosis. ADAMTS (a disintegrin and
metalloproteinase with thrombospondin motifs) is a recently described family of proteinases
that is able to degrade the ECM proteins aggrecan and versican expressed in blood vessels.
The purpose of the present study was to analyze the expression and regulation of several
ADAMTSs before and after macrophage differentiation and after stimulation with IFN-γ, IL-1β …