[HTML][HTML] Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

K Sato, F Okajima - World journal of biological chemistry, 2010 - ncbi.nlm.nih.gov
K Sato, F Okajima
World journal of biological chemistry, 2010ncbi.nlm.nih.gov
The reverse cholesterol transport mediated by high-density lipoprotein (HDL) is an important
mechanism for maintaining body cholesterol, and hence, the crucial anti-atherogenic action
of the lipoprotein. Recent studies, however, have shown that HDL exerts a variety of anti-
inflammatory and anti-atherogenic actions independently of cholesterol metabolism. The
present review provides an overview of the roles of sphingosine 1-phosphate (S1P)/S1P
receptor and apolipoprotein AI/scavenger receptor class B type I systems in the anti …
Abstract
The reverse cholesterol transport mediated by high-density lipoprotein (HDL) is an important mechanism for maintaining body cholesterol, and hence, the crucial anti-atherogenic action of the lipoprotein. Recent studies, however, have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism. The present review provides an overview of the roles of sphingosine 1-phosphate (S1P)/S1P receptor and apolipoprotein AI/scavenger receptor class B type I systems in the anti-atherogenic HDL actions. In addition, the physiological significance of the existence of S1P in the HDL particles is discussed.
ncbi.nlm.nih.gov