Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to
reactive intermediates is crucial to the development of liver injury. However, the events
which lead to hepatocellular toxicity following metabolite formation and covalent binding to
cellular macromolecules remain unknown. The present study was undertaken to investigate
the effect of administered BB and FS on mitochondrial total glutathione (GSH+ GSSG,
henceforth referred to as glutathione) content and respiratory function as potential initiating …