Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man
BH Lauterburg, JR Mitchell - Journal of hepatology, 1987 - Elsevier
In spite of the importance of glutathione (GSH) in the detoxification of toxic metabolites of
drugs, virtually nothing is known about the regulation of hepatic GSH homeostasis in man. In
order to estimate the turnover of hepatic GSH and to assess the effect of different doses of
acetaminophen (paracetamol) on the synthesis of GSH in man,[3 H] cystine and varying
doses of acetaminophen were administered to healthy volunteers, and the time course of the
specific activity of the cysteine moiety of N-acetylcysteinyl-acetaminophen excreted in urine …
drugs, virtually nothing is known about the regulation of hepatic GSH homeostasis in man. In
order to estimate the turnover of hepatic GSH and to assess the effect of different doses of
acetaminophen (paracetamol) on the synthesis of GSH in man,[3 H] cystine and varying
doses of acetaminophen were administered to healthy volunteers, and the time course of the
specific activity of the cysteine moiety of N-acetylcysteinyl-acetaminophen excreted in urine …