Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice
Y Masubuchi, C Suda, T Horie - Journal of hepatology, 2005 - Elsevier
BACKGROUND/AIMS: Although mitochondria have been demonstrated as primary targets in
acetaminophen hepatotoxicity, the mechanism for mitochondria-mediated toxicity has not
been defined. We examined the role of mitochondrial permeability transition (MPT) in the
acetaminophen-induced liver injury. METHODS: Male CD-1 mice were given
intraperitoneally acetaminophen (350mg/kg) without or with cyclosporin A (50mg/kg), a
specific inhibitor of MPT. Serum alanine aminotransferase (ALT), a marker of liver injury, and …
acetaminophen hepatotoxicity, the mechanism for mitochondria-mediated toxicity has not
been defined. We examined the role of mitochondrial permeability transition (MPT) in the
acetaminophen-induced liver injury. METHODS: Male CD-1 mice were given
intraperitoneally acetaminophen (350mg/kg) without or with cyclosporin A (50mg/kg), a
specific inhibitor of MPT. Serum alanine aminotransferase (ALT), a marker of liver injury, and …