[HTML][HTML] Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1
L Xu, CS Kappler, SK Mani, NR Shepherd… - Journal of biological …, 2009 - ASBMB
The NCX1 (sodium-calcium exchanger) is up-regulated in human heart failure and in many
animal models of heart failure. The potential benefits and risks of therapeutically blocking
NCX1 in heart failure and during ischemia-reperfusion are being actively investigated. In this
study, we demonstrate that prolonged administration of the NCX1 inhibitor KB-R7943
resulted in the up-regulation of Ncx1 gene expression in both isolated adult cardiomyocytes
and intact mouse hearts. Ncx1 up-regulation is mediated by the activation of p38 …
animal models of heart failure. The potential benefits and risks of therapeutically blocking
NCX1 in heart failure and during ischemia-reperfusion are being actively investigated. In this
study, we demonstrate that prolonged administration of the NCX1 inhibitor KB-R7943
resulted in the up-regulation of Ncx1 gene expression in both isolated adult cardiomyocytes
and intact mouse hearts. Ncx1 up-regulation is mediated by the activation of p38 …