Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger
KP Roos, MC Jordan, MC Fishbein, MR Ritter… - Journal of cardiac …, 2007 - Elsevier
BACKGROUND: The cardiac sodium–calcium exchanger (NCX1) is a key sarcolemmal
protein for the maintenance of calcium homeostasis in the heart. Because heart failure is
associated with increased expression of NCX1, heterozygous (HET) and homozygous
(HOM) transgenic mice overexpressing NCX1 were developed and evaluated. METHODS
AND RESULTS: The NCX1 transgenic mice display 2.3-fold (HET) and 3.1-fold (HOM)
increases in exchanger activity from wild-type (WT) mice. Functional information was …
protein for the maintenance of calcium homeostasis in the heart. Because heart failure is
associated with increased expression of NCX1, heterozygous (HET) and homozygous
(HOM) transgenic mice overexpressing NCX1 were developed and evaluated. METHODS
AND RESULTS: The NCX1 transgenic mice display 2.3-fold (HET) and 3.1-fold (HOM)
increases in exchanger activity from wild-type (WT) mice. Functional information was …