A controlled study of 9α, 11β-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge
G Bochenek, K Nagraba, E Niżankowska… - Journal of Allergy and …, 2003 - Elsevier
Background: Prostaglandin D2 (PGD2) is the predominant cyclooxygenase product of mast
cells, the number of which is increased in bronchial asthma. Release of PGD2 might reflect
mast cell activation and disordered function of the asthmatic lung. Objective: We sought to
determine blood and urinary levels of 9α, 11β-PGF2, a major stable PGD2 metabolite in 2
well-defined phenotypes of asthma, aspirin-induced asthma (AIA) and aspirin-tolerant
asthma (ATA), and in healthy control subjects and to study the effects of aspirin on PGD2 …
cells, the number of which is increased in bronchial asthma. Release of PGD2 might reflect
mast cell activation and disordered function of the asthmatic lung. Objective: We sought to
determine blood and urinary levels of 9α, 11β-PGF2, a major stable PGD2 metabolite in 2
well-defined phenotypes of asthma, aspirin-induced asthma (AIA) and aspirin-tolerant
asthma (ATA), and in healthy control subjects and to study the effects of aspirin on PGD2 …