Increased urinary excretion of the prostaglandin D2 metabolite 9α, 11β-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway …
S O'Sullivan, B Dahlén, SE Dahlén, M Kumlin - Journal of Allergy and …, 1996 - Elsevier
Prostaglandin (PG) D2 is a major product of arachidonic acid metabolism in pulmonary mast
cells. We therefore attempted to determine whether measurement of the stable urinary
metabolite of PGD2, 9α, 11β-PGF2, could serve as a marker of mast cell activation in the
lungs. A commercially available enzyme immunoassay was validated and found to be
specific and sensitive when applied to unpurified urine. There was no diurnal variation in the
levels of 9α, 11β-PGF2 in healthy volunteers. Morning baseline values of urinary 9α, 11β …
cells. We therefore attempted to determine whether measurement of the stable urinary
metabolite of PGD2, 9α, 11β-PGF2, could serve as a marker of mast cell activation in the
lungs. A commercially available enzyme immunoassay was validated and found to be
specific and sensitive when applied to unpurified urine. There was no diurnal variation in the
levels of 9α, 11β-PGF2 in healthy volunteers. Morning baseline values of urinary 9α, 11β …