Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions
JB Mackic, J Bading, J Ghiso, L Walker… - Vascular …, 2002 - Elsevier
1. We studied cerebrovascular sequestration and blood–brain barrier (BBB) permeability to
[125I]-or [123I]-labeled amyloid-β peptides (Aβ) in aged rhesus and aged squirrel monkey,
the nonhuman primate models of cerebral β-amyloidosis and cerebrovascular amyloid
angiopathy (CAA), respectively. 2. In aged rhesus, the half-time of elimination of [125I] Aβ1–
40, t1/2e, was faster by 1.34 h, the systemic clearance, Clss, increased by 4.21 ml/min/kg
and the mean residence time of intact peptide in the circulation shortened by 2 h. 3 …
[125I]-or [123I]-labeled amyloid-β peptides (Aβ) in aged rhesus and aged squirrel monkey,
the nonhuman primate models of cerebral β-amyloidosis and cerebrovascular amyloid
angiopathy (CAA), respectively. 2. In aged rhesus, the half-time of elimination of [125I] Aβ1–
40, t1/2e, was faster by 1.34 h, the systemic clearance, Clss, increased by 4.21 ml/min/kg
and the mean residence time of intact peptide in the circulation shortened by 2 h. 3 …