[HTML][HTML] Small C-terminal domain phosphatase enhances snail activity through dephosphorylation
Down-regulation of E-cadherin plays an important role in epithelial-mesenchymal transition
(EMT), which is critical in normal development and disease states such as tissue fibrosis and
metastasis. Snail, a key transcription repressor of E-cadherin, is a labile protein with a short
half-life and is regulated through phosphorylation, ubiquitination, and degradation.
Previously, we showed that GSK-3β phosphorylated two stretches of serine residues within
the nuclear export signal and the destruction box of Snail, provoking its cytoplasmic export …
(EMT), which is critical in normal development and disease states such as tissue fibrosis and
metastasis. Snail, a key transcription repressor of E-cadherin, is a labile protein with a short
half-life and is regulated through phosphorylation, ubiquitination, and degradation.
Previously, we showed that GSK-3β phosphorylated two stretches of serine residues within
the nuclear export signal and the destruction box of Snail, provoking its cytoplasmic export …