Systemic and acquired immune responses in Alzheimer's disease

M Britschgi, T Wyss‐Coray - International review of neurobiology, 2007 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by a
progressive cognitive decline and dementia. AD brains are marked by amyloid plaques and
neurofibrillary tangles, neuronal cell loss, and a prominent activation of glial cells, and
innate immune responses. A growing number of studies in AD have also reported alterations
in systemic immune responses including changes in lymphocyte and macrophage
distribution and activation, the presence of autoantibodies, or abnormal cytokine production …