The danger model: a renewed sense of self
P Matzinger - science, 2002 - science.org
P Matzinger
science, 2002•science.orgFor over 50 years immunologists have based their thoughts, experiments, and clinical
treatments on the idea that the immune system functions by making a distinction between
self and nonself. Although this paradigm has often served us well, years of detailed
examination have revealed a number of inherent problems. This Viewpoint outlines a model
of immunity based on the idea that the immune system is more concerned with entities that
do damage than with those that are foreign.
treatments on the idea that the immune system functions by making a distinction between
self and nonself. Although this paradigm has often served us well, years of detailed
examination have revealed a number of inherent problems. This Viewpoint outlines a model
of immunity based on the idea that the immune system is more concerned with entities that
do damage than with those that are foreign.
For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.
AAAS