[HTML][HTML] UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C …
L Yu, L Orlandi, P Wang, MS Orr… - Journal of Biological …, 1998 - ASBMB
We have previously demonstrated that UCN-01, a potent protein kinase inhibitor currently in
phase I clinical trials for cancer treatment, abrogates G 2 arrest following DNA damage. Here
we used murine FT210 cells, which contain temperature-sensitive Cdc2 mutations, to
determine if UCN-01 abrogates G 2 arrest through a Cdc2-dependent pathway. We report
that UCN-01 cannot induce mitosis in DNA-damaged FT210 cells at the non-permissive
temperature for Cdc2 function. Failure to abrogate G 2 arrest was not due to UCN-01 …
phase I clinical trials for cancer treatment, abrogates G 2 arrest following DNA damage. Here
we used murine FT210 cells, which contain temperature-sensitive Cdc2 mutations, to
determine if UCN-01 abrogates G 2 arrest through a Cdc2-dependent pathway. We report
that UCN-01 cannot induce mitosis in DNA-damaged FT210 cells at the non-permissive
temperature for Cdc2 function. Failure to abrogate G 2 arrest was not due to UCN-01 …