Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells
Science, 2007•science.org
CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by
numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is
constitutively expressed on cells of the innate immune system in both mice and humans, and
that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as
an adjuvant during induced immune responses, and Tim-3 ligation induced distinct
signaling events in T cells and dendritic cells; the latter finding could explain the apparent …
numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is
constitutively expressed on cells of the innate immune system in both mice and humans, and
that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as
an adjuvant during induced immune responses, and Tim-3 ligation induced distinct
signaling events in T cells and dendritic cells; the latter finding could explain the apparent …
CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions.
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