Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies

I Rojas, F Graus, F Keime-Guibert, R Rene… - Neurology, 2000 - AAN Enterprises
I Rojas, F Graus, F Keime-Guibert, R Rene, JY Delattre, JM Ramon, J Dalmau, JB Posner
Neurology, 2000AAN Enterprises
Article abstract The outcome of 34 women with anti-Yo–associated paraneoplastic
cerebellar degeneration was reviewed. Three patients had not developed cancer after more
than 4 years of follow-up. The only independent predictor for survival was the type of
associated tumor (risk ratio, 1.79; 95% CI, 1.02 to 3.12). Median survival was 100 months for
patients with breast cancer and 22 for those with gynecologic cancer. Although
paraneoplastic cerebellar degeneration leads to the diagnosis of cancer in 63% of the …
Article abstract The outcome of 34 women with anti-Yo–associated paraneoplastic cerebellar degeneration was reviewed. Three patients had not developed cancer after more than 4 years of follow-up. The only independent predictor for survival was the type of associated tumor (risk ratio, 1.79; 95% CI, 1.02 to 3.12). Median survival was 100 months for patients with breast cancer and 22 for those with gynecologic cancer. Although paraneoplastic cerebellar degeneration leads to the diagnosis of cancer in 63% of the patients, cancer progression was the cause of death in 52%.
American Academy of Neurology