[HTML][HTML] The αβ T cell receptor is an anisotropic mechanosensor
ST Kim, K Takeuchi, ZYJ Sun, M Touma… - Journal of Biological …, 2009 - ASBMB
Thymus-derived lymphocytes protect mammalian hosts against virus-or cancer-related
cellular alterations through immune surveillance, eliminating diseased cells. In this process,
T cell receptors (TCRs) mediate both recognition and T cell activation via their dimeric αβ,
CD3ϵγ, CD3ϵδ, and CD3ζζ subunits using an unknown structural mechanism. Here, site-
specific binding topology of anti-CD3 monoclonal antibodies (mAbs) and dynamic TCR
quaternary change provide key clues. Agonist mAbs footprint to the membrane distal CD3ϵ …
cellular alterations through immune surveillance, eliminating diseased cells. In this process,
T cell receptors (TCRs) mediate both recognition and T cell activation via their dimeric αβ,
CD3ϵγ, CD3ϵδ, and CD3ζζ subunits using an unknown structural mechanism. Here, site-
specific binding topology of anti-CD3 monoclonal antibodies (mAbs) and dynamic TCR
quaternary change provide key clues. Agonist mAbs footprint to the membrane distal CD3ϵ …