The spindle-assembly checkpoint in space and time

A Musacchio, ED Salmon - Nature reviews Molecular cell biology, 2007 - nature.com
A Musacchio, ED Salmon
Nature reviews Molecular cell biology, 2007nature.com
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome
mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent
molecular analyses have begun to shed light on the complex interaction of the checkpoint
proteins with kinetochores—structures that mediate the binding of spindle microtubules to
chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of …
Abstract
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores — structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
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