[PDF][PDF] Cancer: CINful centrosomes

SF Bakhoum, DA Compton - Current Biology, 2009 - cell.com
SF Bakhoum, DA Compton
Current Biology, 2009cell.com
Cancer: CINful Centrosomes Page 1 Saccoglossus is a transitory feature that may correspond
to the larval nervous system of other enteropneusts. This work opens up new avenues of
comparative CNS research. Clearly, these data, together with the inverted BMP patterning in
acorn worms [17], are consistent with the view that the neural plate of the proboscis stem, the
collar cord, the circumesophageal tract and ventral cord together correspond to the chordate
CNS as a whole and to the CNS of other invertebrates where inversion has not occurred, as …
Summary
The regulation of centrosome number is lost in many tumors and the presence of extra centrosomes correlates with chromosomal instability. Recent work now reveals how extra centrosomes cause chromosome mis-segregation in tumor cells.
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