Spindle assembly in animal cells

DA Compton - Annual review of biochemistry, 2000 - annualreviews.org
DA Compton
Annual review of biochemistry, 2000annualreviews.org
▪ Abstract Chromosome segregation during mitosis and meiosis is driven by a complex
superstructure called the spindle. Microtubules are the primary structural component of
spindles, and spindle assembly and function are intimately linked to the intrinsic dynamics of
microtubules. This review summarizes spindle structure and highlights recent findings
regarding the mechanisms and molecules involved in organizing microtubules into spindles.
In addition, mechanisms for chromosome movement and segregation are discussed.
Abstract
Chromosome segregation during mitosis and meiosis is driven by a complex superstructure called the spindle. Microtubules are the primary structural component of spindles, and spindle assembly and function are intimately linked to the intrinsic dynamics of microtubules. This review summarizes spindle structure and highlights recent findings regarding the mechanisms and molecules involved in organizing microtubules into spindles. In addition, mechanisms for chromosome movement and segregation are discussed.
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