Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes

K Paulsson, B Johansson - Pathologie Biologie, 2007 - Elsevier
Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid
leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and
10% of the cytogenetically abnormal cases, respectively. However, despite the high
frequency of+ 8, much remains to be elucidated as regards its epidemiology, etiology,
clinical impact, association with other chromosomal abnormalities, cell of origin, and
functional and pathogenetic consequences. Here, we summarize and review these various …