The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

RP Rother, L Bell, P Hillmen, MT Gladwin - Jama, 2005 - jamanetwork.com
ContextThe efficient sequestration of hemoglobin by the red blood cell membrane and the
presence of multiple hemoglobin clearance mechanisms suggest a critical need to prevent
the buildup of this molecule in the plasma. A growing list of clinical manifestations attributed
to hemoglobin release in a variety of acquired and iatrogenic hemolytic disorders suggests
that hemolysis and hemoglobinemia should be considered as a novel mechanism of human
disease. Evidence AcquisitionPertinent scientific literature databases and references were …