High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

V Kasprowicz, J Schulze zur Wiesch, T Kuntzen… - Journal of …, 2008 - Am Soc Microbiol
V Kasprowicz, J Schulze zur Wiesch, T Kuntzen, BE Nolan, S Longworth, A Berical, J Blum…
Journal of virology, 2008Am Soc Microbiol
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on
hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute
and chronic infections and after the resolved infection stage. PD-1 expression on HCV-
specific T cells was high early in acute infection irrespective of clinical outcome, and most
cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic
expression levels were especially high. Our results suggest that an analysis of PD-1 …
Abstract
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
American Society for Microbiology