Transforming growth factor-β (Tgf-β) signaling is crucial for regulating craniofacial
development. Loss of Tgf-β signaling results in defects in cranial neural crest cells (CNCC),
but the mechanism by which Tgf-β signaling regulates bone formation in CNCC-derived
osteogenic cells remains largely unknown. In this study, we discovered that Tgf-β regulates
the basal transcriptional regulatory machinery to control intramembranous bone
development. Specifically, basal transcription factor Taf4b is down-regulated in the CNCC …