[HTML][HTML] Identification of DC-SIGN, a novel dendritic cell–specific ICAM-3 receptor that supports primary immune responses
TBH Geijtenbeek, R Torensma, SJ van Vliet… - Cell, 2000 - cell.com
TBH Geijtenbeek, R Torensma, SJ van Vliet, GCF van Duijnhoven, GJ Adema, Y van Kooyk…
Cell, 2000•cell.comContact between dendritic cells (DC) and resting T cells is essential to initiate a primary
immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is
important in this first contact with DC. We discovered that instead of the common ICAM-3
receptors LFA-1 and αDβ2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with
high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo,
mediates transient adhesion with T cells. Since antibodies against DC-SIGN inhibit DC …
immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is
important in this first contact with DC. We discovered that instead of the common ICAM-3
receptors LFA-1 and αDβ2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with
high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo,
mediates transient adhesion with T cells. Since antibodies against DC-SIGN inhibit DC …
Abstract
Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is important in this first contact with DC. We discovered that instead of the common ICAM-3 receptors LFA-1 and αDβ2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo, mediates transient adhesion with T cells. Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC–T cell contact zone.
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