How tolerogenic dendritic cells induce regulatory T cells
RA Maldonado, UH von Andrian - Advances in immunology, 2010 - Elsevier
Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become
increasingly recognized for their crucial role as regulators of innate and adaptive immunity.
DCs are exquisitely adept at acquiring, processing, and presenting antigens to T cells. They
also adjust the context (and hence the outcome) of antigen presentation in response to a
plethora of environmental inputs that signal the occurrence of pathogens or tissue damage.
Such signals generally boost DC maturation, which promotes their migration from peripheral …
increasingly recognized for their crucial role as regulators of innate and adaptive immunity.
DCs are exquisitely adept at acquiring, processing, and presenting antigens to T cells. They
also adjust the context (and hence the outcome) of antigen presentation in response to a
plethora of environmental inputs that signal the occurrence of pathogens or tissue damage.
Such signals generally boost DC maturation, which promotes their migration from peripheral …