Interleukin-2 and interleukin-15: immunotherapy for cancer
TA Fehniger, MA Cooper, MA Caligiuri - Cytokine & growth factor reviews, 2002 - Elsevier
Interleukin (IL)-2 and IL-15 are two cytokine growth factors that regulate lymphocyte function
and homeostasis. Early clinical interest in the use of IL-2 in the immunotherapy of renal cell
carcinoma and malignant melanoma demonstrated the first efficacy for cytokine
monotherapy in the treatment of neoplastic disease. Advances in our understanding of the
cellular and molecular biology of IL-2 and its receptor complex have provided rationale to
better utilize IL-2 to expand and activate immune effectors in patients with cancer. Exciting …
and homeostasis. Early clinical interest in the use of IL-2 in the immunotherapy of renal cell
carcinoma and malignant melanoma demonstrated the first efficacy for cytokine
monotherapy in the treatment of neoplastic disease. Advances in our understanding of the
cellular and molecular biology of IL-2 and its receptor complex have provided rationale to
better utilize IL-2 to expand and activate immune effectors in patients with cancer. Exciting …