Clinical and biological significance of GSK-3β inactivation in breast cancer—an immunohistochemical study
H Armanious, J Deschenes, P Gelebart, S Ghosh… - Human pathology, 2010 - Elsevier
Glycogen synthase kinase 3β, recently found to be functionally abnormal in various types of
human disease, is negatively regulated by the PI3K/Akt signaling pathway. As Akt is
constitutively activated in a subset of breast cancer, we hypothesized that glycogen synthase
kinase 3β is inappropriately inactivated in these cases. In this study, we aimed to assess (1)
the overall frequency of glycogen synthase kinase 3β inactivation in breast cancer;(2)
whether there is an association between Akt activation and glycogen synthase kinase 3β …
human disease, is negatively regulated by the PI3K/Akt signaling pathway. As Akt is
constitutively activated in a subset of breast cancer, we hypothesized that glycogen synthase
kinase 3β is inappropriately inactivated in these cases. In this study, we aimed to assess (1)
the overall frequency of glycogen synthase kinase 3β inactivation in breast cancer;(2)
whether there is an association between Akt activation and glycogen synthase kinase 3β …