Avian sarcoma virus 17 carries the jun oncogene.
Y Maki, TJ Bos, C Davis… - Proceedings of the …, 1987 - National Acad Sciences
Y Maki, TJ Bos, C Davis, M Starbuck, PK Vogt
Proceedings of the National Academy of Sciences, 1987•National Acad SciencesBiologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a
replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag
and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun.
The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also
shows no significant nucleic acid homology with other known oncogenes. The probable
transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion …
replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag
and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun.
The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also
shows no significant nucleic acid homology with other known oncogenes. The probable
transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion …
Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.
National Acad Sciences