[HTML][HTML] Functional Analysis of Burkitt's Lymphoma Mutant c-Myc Proteins (∗)

B Smith-S, EM Hijmans, RL Beijersbergen… - Journal of Biological …, 1996 - ASBMB
The c-myc gene encodes a sequence-specific DNA binding protein that activates
transcription of cellular genes. Transcription activation by Myc proteins is regulated by
phosphorylation of serine and threonine residues within the transactivation domain and by
complex formation with the retinoblastoma-related protein p107. In Burkitt's lymphoma,
missense mutations within the c-Myc transactivation domain have been found with high
frequency. It has been reported that mutant c-Myc proteins derived from Burkitt's lymphoma …