c-MYC: more than just a matter of life and death

S Pelengaris, M Khan, G Evan - Nature Reviews Cancer, 2002 - nature.com
S Pelengaris, M Khan, G Evan
Nature Reviews Cancer, 2002nature.com
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often
associated with poor prognosis, indicating a key role for this oncogene in tumour
progression. However, as established human tumours often bear multiple genetic lesions, it
is difficult to determine whether c-MYC is instrumental in the initiation/progression of the
tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable
transgenic mouse models of oncogenesis have shed light on these issues and provide hope …
Abstract
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.
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