[HTML][HTML] A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27kip1 and regulates RhoA activation, actin remodeling, and matrigel …
D Hoshino, T Tomari, M Nagano, N Koshikawa… - Journal of biological …, 2009 - ASBMB
Pericellular proteolysis by membrane-type 1 matrix metalloproteinase (MT1-MMP) plays a
pivotal role in tumor cell invasion. Localization of MT1-MMP at the invasion front of cells, eg
on lamellipodia and invadopodia, has to be regulated in coordination with reorganization of
the actin cytoskeleton. However, little is known about how such invasion-related actin
structures are regulated at the sites where MT1-MMP localizes. During analysis of MT1-MMP-
associated proteins, we identified a heretofore uncharacterized protein. This protein, which …
pivotal role in tumor cell invasion. Localization of MT1-MMP at the invasion front of cells, eg
on lamellipodia and invadopodia, has to be regulated in coordination with reorganization of
the actin cytoskeleton. However, little is known about how such invasion-related actin
structures are regulated at the sites where MT1-MMP localizes. During analysis of MT1-MMP-
associated proteins, we identified a heretofore uncharacterized protein. This protein, which …